Inhibition of human sterol delta 7-reductase and other post-lanosterol enzymes by 2-(4- phenethylpiperazin-1-yl)-1-(pyridine-3-yl)ethanol (LK-980), a novel inhibitor of cholesterol synthesis

Centre for Functional Genomics and Bio-Chips, Institute of Biochemistry, Faculty of Medicine, Zaloska 4, SI-1000 Ljubljana, University of Ljubljana, Slovenia (J.A., D.R.) Lek Pharmaceuticals d. d., Drug Discovery, Verovskova 57, SI-1000 Ljubljana, Slovenia (T.K., M.S., U.U.) L14 Laboratory for Biomolecular Structure, National Institute of Chemistry, EN->FIST Center of Excellence, SI-1000 Ljubljana, Slovenia (D.K.) Division of Clinical Chemistry, Karolinska Institutet, Div. of clinical chemistry, C1-62, SE14186 Stockholm, Huddinge, Sweden (I.B.) Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri út 59-67., III épület, 1.emelet 106, HU-1025, Budapest, Hungary (K.M., P.S.) Faculty of Electrical Engineering, Trzaska 25, SI-1000 Ljubljana, University of Ljubljana, Slovenia (A.B.) Institute of Functional Genomics, Centre National de la Recherche Scientifique (CNRS) UMR5203 ; Institut National de la Santé et de la Recherche Médicale (INSERM) U661, University Montpellier 1 and 2, Montpellier, France (J.-M.P.) DMD Fast Forward. Published on October 15, 2010 as doi:10.1124/dmd.110.035840